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朱虎成,博士,教授,博士生导师,新2会员管理端10888党委副书记,国家自然科学基金优秀青年基金及湖北省杰出青年基金获得者。主要从事药用植物和真菌来源活性天然药物的提取分离、结构鉴定及药理活性研究。主持国家自然科学基金优秀青年基金、面上项目,湖北省科技重大项目、省杰出青年基金等。以第一作者或通讯作者身份在Angew. Chem. Int. Ed.和Org. Lett.等学术期刊上发表SCI论文90余篇。现任天然药物化学与资源评价湖北省重点实验室副主任,湖北省药学会中药天然药专业委员会副主任委员。
联系方式
邮箱:zhuhucheng@hust.edu.cn
研究方向
药用植物和真菌来源活性天然药物的分离鉴定及药理活性研究
教育及工作经历
2024.1-至今,华中科技大学,同济新2会员管理端10888,党委副书记
2021.4-2023.12,华中科技大学,同济新2会员管理端10888,院长助理
2019.10-至今,华中科技大学,同济新2会员管理端10888,教授
2016.9-2019.9,华中科技大学,同济新2会员管理端10888,副教授
2014.7-2016.8,华中科技大学,同济新2会员管理端10888,博士后
2011.9-2014.6,华中科技大学,同济新2会员管理端10888,博士
2008.9-2011.6,西南大学,新2会员管理端10888,硕士
2004.9-2008.6,西南交通大学,生物工程系,本科
主持科研项目
国家自然科学基金面上项目,编号82173706,2022.1-2025.12(55万)
国家自然科学基金优秀青年基金,编号81922065,2020.1-2022.12(120万)
国家自然科学基金面上项目,编号21772048,2018.1-2021.12(66万)
国家自然科学基金青年项目,编号21502057,2016.1-2018.12(21万)
湖北省科技重大项目,编号2021ACA012,2021.7-2024.6(1000万)
湖北省杰出青年基金项目,编号2018CFA076,2018.3-2021.3(10万)
中国博士后科学基金特别资助,编号2016T90695,2016.1-2016.12(15万)
中国博士后科学基金面上项目,编号2015M572154,2015.7-2016.6(5万)
主要学术论文
[1] Hucheng Zhu(#), Chunmei Chen(#), Qingyi Tong(#), Jing Yang, Guangzheng Wei, Yongbo Xue, Jianping Wang, Zengwei Luo, and Yonghui Zhang(*), Asperflavipine A, A Cytochalasan Heterotetramer Uniquely Defined by a Highly Complex Tetradecacyclic Ring System fromAspergillus flavipesQCS12,Angewandte Chemie-International Edition,2017, 56, 5242 –5246.
[2] Hucheng Zhu(#), Chunmei Chen(#), Qingyi Tong, Xiao-Nian Li, Jing Yang, Yongbo Xue, Zengwei Luo, Jianping Wang, Guangmin Yao, Yonghui Zhang(*), Epicochalasines A and B, Two Bioactive Merocytochalasans Bearing Caged Epicoccine Dimer Units fromAspergillus flavipes,Angewandte Chemie International Edition, 2016, 55, 3486-3490.
[3] Hucheng Zhu(#), Chunmei Chen(#), Yongbo Xue(#), Qingyi Tong, Xiao-Nian Li, Xintao Chen, Jianping Wang, Guangmin Yao, Zengwei Luo, Yonghui Zhang(*), Asperchalasine A, a Cytochalasan Dimer with an Unprecedented Decacyclic Ring System, fromAspergillus flavipes,Angewandte Chemie International Edition, 2015, 54, 13374-13378.
[4] Yi Guo(#), Fang Huang(#), Weiguang Sun, Yuan Zhou, Chunmei Chen, Changxing Qi, Jing Yang, Xiao-Nian Li, Zengwei Luo,Hucheng Zhu(*), Xiaochuan Wang(*), Yonghui Zhang(*). Unprecedented polycyclic polyprenylated acylphloroglucinols with anti-Alzheimer's activity from St. John's wort,Chemical Science,2021,12, 11438.
[5] Qin Li(#), Mi Zhang(#), Xiaotian Zhang(#), Lanqin Li, Meijia Zheng, Jinbing Kang, Fei Liu, Qun Zhou, Xiaonian Li, Weiguang Sun, Junjun Liu, Chunmei Chen(*),Hucheng Zhu(*), Yonghui Zhang(*). Talaroclauxins A and B: Duclauxin-ergosterol and duclauxin-polyketide hybrid metabolites with complicated skeletons fromTalaromyces stipitatus.Chinese Chemical Letters,2024, 35, 108193.
[6] Aimin Fu(#), Chunmei Chen(#), Qin Li(#), Nanjin Ding, Jiaxin Dong, Yu Chen, MengshaWei, Weiguang Sun(*),Hucheng Zhu(*), Yonghui Zhang(*). Niduenes A−F, six functionalized sesterterpenoids with a pentacyclic 5/5/5/5/6 skeleton from endophytic fungusAspergillus nidulans.Chinese Chemical Letters,2023, 109100.
[7] Qin Li(#), Meijia Zheng(#), Fengli Li(#), Yongqi Li, Chunmei Chen, Zijian Huang, Junjun Liu, Weiguang Sun(*), Ying Ye(*),Hucheng Zhu(*), Yonghui Zhang(*). Talarolactones A–G, α-Pyrone Dimers with Anti-inflammatory Activities from Talaromyces adpressus, and Their Biosynthetic Pathways,Organic Letters, 2023, 25,1616–1621.
[8] Qin Li, Aimin Fu, Mengsha Wei, Yang Xiao, Jie Yin, Jianzheng Huang, Xiao-Nian Li, Qingyi Tong, Chunmei Chen(*),Hucheng Zhu(*), Yonghui Zhang(*). Asperemestrins A−D, Emestrin Hybrid Polymers with Bridged Skeletons from the Endophytic FungusAspergillus nidulans,Organic Letters, 2022, 24, 6800–6804.
[9] Huaqiang Li(#), Wenya Feng(#), Xiaoxin Li, Xin Kang, Shan Yan, Menghang Chao, Shuyuan Mo, Weiguang Sun, Yuanyuan Lu, Chunmei Chen, Jianping Wang(*),Hucheng Zhu(*), and Yonghui Zhang(*), Terreuspyridine: An Unexpected Pyridine-Fused Meroterpenoid Alkaloid with a Tetracyclic 6/6/6/6 Skeleton fromAspergillus terreus,Organic Letters, 2020 22, 7041-7046.
[10] Zhaodi Wu(#), Xiaotian Zhang(#), Chunmei Chen(#), Peng Zhou, Mi Zhang, Lianghu Gu, Zengwei Luo, Jianping Wang, Qingyi Tong(*),Hucheng Zhu(*), and Yonghui Zhang(*), Dimericchalasine A and Amichalasines D and E, Unexpected Cytochalasan Homodimer and Heterotrimers fromAspergillus micronesiensisPG-1,Organic Letters, 2020 22, 2162-2166.
[11] Qin Li(#), Chunmei Chen(#), Yan He, Danyingzi Guan, Li Cheng, Xincai Hao, Mengsha Wei, Yinyu Zheng, Chang Liu, Xiao-Nian Li, Qun Zhou,Hucheng Zhu(*), and Yonghui Zhang(*), Emeriones A−C, Three Highly Methylated Polyketides with Bicyclo[4.2.0]octene and 3,6-Dioxabicyclo[3.1.0]hexane Functionalities fromEmericella nidulans,Organic Letters, 2019, 21, 5091-5095.
[12] Qin Li(#), Chunmei Chen(#), Mengsha Wei, Chong Dai, Li Cheng, Jiafeng Tao, Xiao-Nian Li, Jianping Wang, Weiguang Sun(*),Hucheng Zhu(*), and Yonghui Zhang(*), Niduterpenoids A and B, Two Sesterterpenoids with a Highly Congested Hexacyclic 5/5/5/5/3/5 Ring System from the FungusAspergillus nidulans,Organic Letters, 2019, 21, 2290-2293.
[13] Zhaodi Wu(#), Qingyi Tong(#), Xiaotian Zhang, Peng Zhou, Chong Dai, Jianping Wang, Chunmei Chen(*),Hucheng Zhu(*), and Yonghui Zhang(*),Amichalasines A–C, Three Cytochalasan Heterotrimers fromAspergillus micronesiensisPG-1,Organic Letters, 2019, 21, 1026-1030.
[14] Wenjing Wang, Fanrong Zeng, Qiong Bie, Chong Dai,Chunmei Chen, Qingyi Tong, Junjun Liu, Jianping Wang, Yuan Zhou,Hucheng Zhu(*), Yonghui Zhang(*), Cytochathiazines A−C, Three Merocytochalasans with a 2H-1,4-Thiazine Functionality from Coculture ofChaetomium globosumandAspergillus flavipes,Organic Letters, 2018, 20, 6817-6821.
[15] Zhengxi Hu(#), Weiguang Sun(#), Fengli Li(#), Jiankun Guan(#), Yuanyuan Lu, Junjun Liu, Ying Tang, Guang Du, Yongbo Xue, Zengwei Luo, Jianping Wang(*),Hucheng Zhu(*), and Yonghui Zhang(*),Fusicoccane-Derived Diterpenoids fromAlternaria brassicicola, Investigation of the Structure-Stability Relationship and Discovery of a IKKβ Inhibitor,Organic Letters, 2018, 20, 5198-5202.
[16] Yi Zang, Gregory Genta-Jouve, Yingyu Zheng, Qing Zhang, Chunmei Chen, Qun Zhou, Jianping Wang(*),Hucheng Zhu(*), Yonghui Zhang(*). Griseofamines A and B, Two indole-tetramic acid alkaloids with 6/5/6/5 and 6/5/7/5 ring systems fromPenicillium griseofulvum,Organic Letters, 2018, 20, 2046-2050.
[17] Keliang Chen(#), Xuwen Zhang(#), Weiguang Sun(#), Junjun Liu, Jing Yang, Chunmei Chen, Xiulan Liu, Limin Gao, Jianping Wang, Hua Li, Zengwei Luo, Yongbo Xue,Hucheng Zhu(*), and Yonghui Zhang(*), Manginoids A–G, Seven Monoterpene-Shikimate-Conjugated Meroterpenoids with a Spiro Ring System fromGuignardia mangiferae,Organic Letters, 2017, 19, 5956-5959.
[18] Guangzheng Wei(#), Chunmei Chen(#), Qingyi Tong(#), Jinfeng Huang, Wenjing Wang, Zhaodi Wu, Jing Yang, Junjun Liu, Yongbo Xue, Zengwei Luo, Jianping Wang,Hucheng Zhu(*), and Yonghui Zhang(*), Aspergilasines A–D, four merocytochalasans with new carbon skeletons fromAspergillus flavipesQCS12,Organic Letters, 2017, 19, 4399-4402.
[19] Chunmei Chen(#),Hucheng Zhu(#), Xiao-Nian Li, Jing Yang, JianpingWang, Gentao Li, Yan Li, Qingyi Tong, Guangmin Yao, Zengwei Luo, Yongbo Xue(*), Yonghui Zhang(*),Armochaeglobines A and B, Two New Indole-Based Alkaloids from the Arthropod-Derived FungusChaetomium globosum,Organic Letters, 2015, 17, 644-647.
[20] Hucheng Zhu, Chunmei Chen, Jing Yang, Xiao-Nian Li, Junjun Liu, Bin Sun, Sheng-Xiong Huang, Dongyan Li, Guangmin Yao, Zengwei Luo, Yan Li, Jinwen Zhang, Yongbo Xue(*), Yonghui Zhang(*),Bioactive Acylphloroglucinols with Adamantyl Skeleton fromHypericum Sampsonii,Organic Letters, 2014, 16, 6322-6325.